By using the Liquisolid technique, sustained drug delivery systems were developed for the water soluble drugs in which hydrophobic non-volatile solvents are. Abstract. Liquisolid technique is also known as powder solution technology. It is the technique which deals with the solubility enhancement of poorly soluble. Acta Pharm. Mar;57(1) Liquisolid technique as a tool for enhancement of poorly water-soluble drugs and evaluation of their physicochemical.
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Pharmaceutical applications of liquisolid technique
Solubility is major challenge for the pharmaceutical industry with the developments of new pharmaceutical products. Bio-Pharmaceutical classification class II water insoluble ,iquisolidthe rate of oral absorption is often controlled by the rate in the GIT.
The powder was allowed to flow through the funnel freely into the surface. For the characterization of crystalline state, X-ray diffraction XRD patterns are determined for physical mixture of drug and excipients used in formulation and for the prepared liquisolid compacts.
Such liquid medication is added to the carrier coating material admixture and blended. The angle of repose physical mixtures of liquisolid compacts were determined by fixed funnel method. The compressibility index has been proposed as an indirect measure of bulk density, size and shape, surface area, moisture content and cohesiveness of material because all of these ca influence the compressibility index.
The first two groups may exist or be produced by changing drug solutions and drug suspensions while the third is produced from the formulation of liquid drugs into liquisolid systems.
The Liquisolid technique: an overview
Large amounts of these carriers are necessary for regenerating liquid medication to dry looking and non adherent powder. Effect of powder substrate on the dissolution properties of methyclothiazide liquisolid compacts. During this study many researchers observed that if there is low drug concentration in liquid formulation then there is rapid drug release from the formulation.
In-vitro and ex-vivo characterization, Powder Technology, ; Dissolution profile enhancement occurs in the presence of low levels of hydrophilic carrier, where coating material is not significant.
LIQUISOLID TECHNIQUE: AN APPROACH FOR ENHANCEMENT OF SOLUBILITY
Mainly liquisolid technique is used for drug candidates comes under class II and class IV drugs. Adsorption is the phenomenon in which liquid is not truly absorbed and instead of being dispersed through out the interior of the solid, the molecules only cling to its available surface, internal and external.
This procedure liauisolid the fixed height of each liquisolid powder substrate with prepared and fixed weight. Alkali metal salts of acidic drugs like penicillin and strong acid salts of basic drugs like atropine are more water soluble tcehnique parent drugs.
Lower R values of liquisolid compacts contain relatively smaller amounts of carrier powder cellulosea large amount of fine coating particles silicaand the ratios of their liquid medication per powder substrate are relatively higher.
Moreover, this technique has been explored as an instrument to reduce the pH variation effect on drug release. The graduated cylinder was then allow to tap liqiisolid constant velocity until a constant volume is techhnique, when the powder was considered to have reached the most stable arrangement, the final bulk volume was recorded. We have no conflict of Interest.
These samples are then analyzed by using infra red spectrophotometer or differential scanning Calorimetry. In-vivo evaluation of hydrochlorothiazide liquisolid tablet in beagles dogs.
Deagglomeration behavior of relatively insoluble benzoic acid and its sodium salt. Liquisolid technique as a new approach hechnique sustain propranolol hydrochloride release from tablet matrices.
Announcements Editorial Board Indexing Contact. The height and diameter of the powder cone was measured and angle of repose was calculated. United State Patent, ;All the contents of this journal, except where otherwise noted, is licensed under a Creative Commons Attribution License.
Furthermore, it also retards the drug liuqisolid, i. The height of the funnel was adjusted in such a way that the tip of the funnel just touches the apex liquisoldi the heap of the powder. Liquisolid system demonstrated for drugs which would enhance the dissolution profile and the absorption capacity of water insoluble solid drugs such as digoxin, digitoxin, prednisolone, hydrocortisone, famotidine, carbamazepine, water insoluble vitamins, hydrochlorothiazide, Domperadone, spiranolactone, Carvedilol, Naproxen, and Meloxicam.
It is the technique which deals with the solubility enhancement of poorly soluble drugs. Hence can give dry, non adherent, free flowing powder particles. Enhancement of solubility and dissolution rate of frusemide through liquisolid technique. At near critical temperature, SCFs are highly compressible allowing moderate changes in pressure to greatly alter the density and mass transport characteristics of a fluid that determines its liquiso,id power.